Warburg’s Ghost—Cancer’s Self-Sustaining Phenotype: The Aberrant Carbon Flux in Cholesterol-Enriched Tumor Mitochondria via Deregulated Cholesterogenesis
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چکیده
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Self-Association of Cholesterol in Carbon Tetrachloride
Analysis of infrared hydroxyl multimer absorbances of dilute solutions of cholesterol in car bon tetrachloride as a function of the monomer absorbance strongly favours the interpretation of the association of this alcohol with a monomer-dimer-tetramer model up to a molar fraction of 0.012. This model also explains very well the concentration dependence of the apparent dipole moment. Equilibrium...
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Mitochondria isolated from rapidly growing, poorly differentiated Morris hepatoma 3924A have been found to export the citrate they generate from pyruvate, at a rate greater than four times that of control liver preparations. These 3924A mitochondria fail to exhibit state 3 respiration when either pyruvate or citrate are supplied as respiratory fuels. Nevertheless, substrates that join the Krebs...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2021
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.626316